The Simple Substitution Cipher is a classical monoalphabetic substitution cipher. It replaces each plaintext letter with the letter in the same position of a shuffled cipher alphabet. For English, the normal alphabet is ABCDEFGHIJKLMNOPQRSTUVWXYZ, while the key might be QWERTYUIOPASDFGHJKLZXCVBNM.
To encrypt, find a plaintext letter in the normal alphabet and take the matching letter from the key. With the QWERTY key, A becomes Q, B becomes W, C becomes E, and so on. To decrypt, reverse the lookup: find the ciphertext letter in the key and convert it back to the letter in the normal alphabet.
The same substitution table is used for the whole message, which is why this method is called monoalphabetic. Spaces, punctuation, digits, and other non-alphabet characters are preserved unchanged, and letter case is kept in the output.